Biomarkers of Chronic and Complex Diaseases


Cycle XXXVII (2021/2022)


DETAILS OF A.Y. 2021/2022 PH.D. PROGRAMME IN “Biomarkers of Chronic and Complex Diaseases”

EDUCATIONAL OBJECTIVES Chronic and complex diseases are pathologies with a multi-factorial etiological origin and constitute the most common human pathologies in the world (Global Status Report on NCD, WHO 2010,, representing on their own about 80% of the load of disease of European national health systems. are some of the priorities of the World Health Organization (2008-2013 Action Plan for the Global Strategy for the Prevention and Control of Non-infectious Diseases). Chronic and complex diseases as a priority target for the global health economy, the WHO has indeed stated that: a) “their treatment does not exist or existing therapies are insufficiently effective” and b) “these are diseases where basic and clinical research together they are necessary to establish new biomarkers “. Therefore the PhD course will be aimed at training research doctoral figures who (a) have a complete  understanding of the cellular and molecular mechanisms of chronic and complex diseases, in order to identify new biomarkers and which (b) are able to use the most modern technologies and investigation tools for solving complex scientific problems in this area. The skills acquired will be multidisciplinary in order to train highly qualified personnel for research in the university and private sectors.
Curriculum 1

Coordinator: Umberto Aguglia

Analysis of imaging data, neurophysiological biosignals and molecular profiling for the identification of biomarkers applied to Neurosciences.

Main objectives: Identification of new imaging biomarkers for the diagnosis of neurological diseases.

Curriculum 2

Coordinator: Arturo Pujia

New biomedical technologies for identifying dysmetabolic and nutritional disease
Main objectives: Identification and validation of markers for response to interventions on hepatic steatosis or complicated obesity; New biomedical technologies for the identification of diagnostic markers of insulin resistance and metabolic syndrome.
Curriculum 3

Coordinator: Marta L. Hribal

Molecular and physiopathological aspects of chronic-degenerative and inflammatory diseases

Main objectives: Mechanisms of damage and regeneration of pancreatic beta-cells; Genetic predisposition and low-grade chronic inflammation in chronic-degenerative diseases.

Curriculum 4

Coordinator: Daniele Torella

Chronic cardio-pulmonary diseases and biotechnological and engineering solutions for regenerative medicine.

Main objectives: Identification of new biomarkers for chronic cardiovascular and pulmonary diseases; Molecular mechanisms of coronary stenosis / restenosis; Biotechnological approaches for cardiac regeneration.

Curriculum 5

Coordinator: Mario Cannataro

Methods and techniques of computer engineering for processing, management and for efficient analysis data.

Main objectives: Big Data in bioinformatics and medical informatics; Data mining / deep learning analysis of omics and clinical data; Analysis and alignment of biological networks.

Programme Duration 3 years
Coordinator Prof. Daniele Torella

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